| 心脏病患者心包组织分泌内皮素的研究 |
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| 引用本文： | 刘洁琳,刘雅,王佐广,文杰,王世奇,陈新军,刘亚萍,张维君,温绍君.心脏病患者心包组织分泌内皮素的研究[J].中华心血管病杂志,2008,36(10). |
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| 作者姓名： | 刘洁琳 刘雅 王佐广 文杰 王世奇 陈新军 刘亚萍 张维君 温绍君 |
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| 作者单位： | 北京市心肺血管疾病研究所,高血压研究室,首都医科大学附属北京安贞医院,100029 |
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| 摘 要： | 目的 探讨人心包间皮细胞能否分泌内皮素(ET).方法 利用放射免疫分析方法 分别检测行心内直视术的51例心脏病患者心包液、血浆和心包组织的ET含量,利用原位杂交方法 观察患者心包组织是否存在ET mRNA的表达.结果 心脏病患者心包液中ET浓度显著高于血浆中ET浓度分别为(128.8±44.0)ng/L及(93.7±28.6)ns/L,P＜0.001];心脏病患者心包组织中含有高浓度的ET(510.3±156.7)ng/kg];心脏病患者心包组织浆膜层间皮细胞的胞浆中存在ET mRNA的表达.结论 心脏病患者心包液和心包组织中含有高浓度的ET;人心包组织问皮细胞可以分泌ET.
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| 关 键 词： | 心包 内皮缩血管肽类 |
Pericardial endothelin secretion In patients underwent open heart surgery |
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| LIU Jie-lin,LIU Ya,WANG Zuo-guang,WEN Jie,WANG Shi-qi,CHEN Xin-jun,LIU Ya-ping,ZHANG Wei-jun,WEN Shao-jun.Pericardial endothelin secretion In patients underwent open heart surgery[J].Chinese Journal of Cardiology,2008,36(10). |
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| Authors: | LIU Jie-lin LIU Ya WANG Zuo-guang WEN Jie WANG Shi-qi CHEN Xin-jun LIU Ya-ping ZHANG Wei-jun WEN Shao-jun |
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| Abstract: | Objective To evaluate pericardial endothelin (ET) secretion by the human pericardial mesothelial cells.Methods Plasma,pericardial fluid and pericardial tissue were obtained in 51 patients receiving open heart surgery (coronary artery bypass grafting,elective heart valvuloplasty or valve replacement).ET concentrations in the plasma,pericardial fluid and pericardial tissues were measured by radioimmunoassay (RIA).ET mRNA expression in the human pericardium was detected by in situ hybridization.Results (1) The levels of ET in human pericardial fluid was significantly higher than that in the plasma(128.8±44.0) ng/L vs.(93.7±28.6) ng/L,P＜0.001];(2) ET concentration in the pericardial tissue was (510.3±156.7) ng/kg;(3) In situ hybridization technique evidenced the abundant ET mRNA expression in human pericardial mesothelial cells.Conclusion The study indicated that pericardium secreted ET into the pericardial space. |
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| Keywords: | Pericardium Endothehns |
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