美托洛尔联合曲美他嗪治疗86例缺血性心力衰竭患者的疗效及预后分析

目的探讨美托洛尔联合曲美他嗪治疗86例缺血性心力衰竭患者的疗效及预后。方法选择172例缺血性心力衰竭患者,随机分为试验组(n=86)和对照组(n=86)。对照组使用曲美他嗪治疗,试验组联合美托洛尔治疗,连续治疗12周。比较2组收缩压(SBP)、舒张压(DBP)、心率(HR)及超声心电图检查结果及临床疗效。随访1年,记录脑梗死发病率。结果治疗后,2组SBP、DBP、HR及超声心电图检查结果较治疗前均显著改善(P0.05);试验组SBP、DBP、HR均显著低于对照组(P0.05);试验组左心室缩短分数(FS)、每博输出量(SV)、每分输出量(CO)、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)、左室射血分数(LEVF)均显著优于对照组(P0.05);观察组总有效率显著高于对照组(P0.05);观察组脑梗死发生率显著低于对照组(P0.05)。结论在缺血性心力衰竭患者中应用美托洛尔联合曲美他嗪的效果显著,有助于预防脑梗死。

Efficacy and prognostic analysis of metoprolol combined with trimetazidine in treating 86 patients with ischemic heart failure

Objective To study efficacy and prognostic analysis of metoprolol combined with trimetazidine in treating 86 patients with ischemic heart failure.Methods A total of 172 patients with ischemic heart failure in our hospital were randomly divided into experimental group (n =86) and control group (n =86).On the basis of conventional symptomatic treatment,the control group was treated with trimetazidine,while the observation group was combined with metoprolol,continuous treatment was lasted for 12 weeks.The systolic blood pressure (SBP),diastolic blood pressure (DBP),heart rate (HR),ultrasonic cardiogram and clinical efficacy between the two groups were-compared.After 1 year of follow-up,the incidence of cerebral infarction was recorded.Results The results of SBP,DBP,HR and ultrasonic cardiogram in the two groups were significantly improved compared with treatment before (P ＜ 0.05);The SBP,DBP and HR in the experimental group were significantly lower than that of the control group (P ＜ 0.05);The ultrasonic cardiogram,the left ventricular fractional shortening (FS),stroke volume (SV),cardiac output (CO),left ventricular end diastolic volume (LVEDV),left ventricular end systolic volume (LVESV),left ventricular ejection fraction (LEVF) were significantly better than that of the control group,the differences were statistically significant (P ＜ 0.05);The total effective rate in the observation group was significantly higher than that of the control group (P ＜ 0.0 5),the follow-up showed that the incidence of cerebral infarction in the observation group was significantly lower than that of the control group (P ＜ 0.05).Conclusion The effect of metoprolol combined with trimetazidine is significant for ischemic heart failure,and it's helpful for prevention of cerebral infarction.