滋阴降火法对阴虚内热证系统性红斑狼疮患者细胞因子IL-10、IL-18的影响

目的观察滋阴降火法对阴虚内热证系统性红斑狼疮患者细胞因子白细胞介素-10(IL-10)、白细胞介素-18(IL-18)的影响。方法选取86例阴虚内热证系统性红斑狼疮患者,按随机数表法分为对照组(n=43)和研究组(n=43)。对照组采用常规西医治疗,研究组在对照组基础上采用滋阴降火法治疗。比较2组中医症候积分、细胞因子IL-10、IL-18水平的变化情况及不良反应发生情况,并评价2组临床疗效。结果治疗后,2组细胞因子IL-10、IL-18均显著下降,且研究组下降幅度较对照组更显著(P0.05)。研究组临床疗效总有效率为95.35%,显著高于对照组69.77%(P0.05)。研究组不良反应发生率为6.98%,与对照组9.30%相比,差异无统计学意义(P0.05)。结论对阴虚内热证系统性红斑狼疮患者采用滋阴降火法治疗,可显著提高临床疗效,缓解临床症状,且不会增加不良反应的发生。

Effect of yin-tonifying and fire-removing prescription on IL-10 and IL-18 in systemic lupus erythematosus patients with syndrome of internal heat due to yin deficiency

Objective To observe the effect of yin-tonifying and fire-removing prescription on IL-10 and IL-18 in systemic lupus erythematosus patients with syndrome of internal heat due to yin deficiency.Methods A total of 86 systemic lupus erythematosus patients with syndrome of internal heat due to yin deficiency were enrolled and randomly divided into control group and research group,43 cases in each group.The control group was treated with conventional western medicine,while research group was treated with yin-tonifying and fire-removing prescription on basis of control group.The TCM symptom score,serum IL-10 and IL-18 levels and the incidence rate of adverse reactions were compared between the two groups.The clinical efficacy of the two groups was evaluated.Results Mter treatment,the levels of IL-10 and IL-18 in both group decreased significantly,and the levels in research group were significantly lower than control group (P ＜ 0.05).The total effective rate was 95.35％ in research group,which was significantly higher than 69.77％ in the control group (P ＜ 0.05).The incidence rate of adverse reactions was 6.98％ in the research group,whichwas similar to 9.30％ in the control group (P ＞ 0.05).Conclusion For systemic lupus erythematosus patients with syndrome of internal heat due to yin deficiency,yin-tonifying and fire-removing prescription can significantly improve the clinical efficacy,alleviate clinical symptoms,and will not increase the incidence rate of adverse reactions.