流感病毒与金黄色葡萄球菌共感染致病机制研究进展

近年研究表明,流感病毒与细菌共感染是导致流感流行期间高死亡率的重要原因.目前已报道能与流感发生共感染的细菌至少有12种,其中与金黄色葡萄球菌的共感染不仅最为常见,且致死率最高.流感病毒与金葡菌共感染除能诱发严重肺炎外,还能降低机体对病原或炎症损伤的耐受能力,而且此两种病原也能协同加重对机体的毒理损伤作用.该文结合近年来相关研究进展,对流感病毒/金葡菌共感染导致高死亡率的致病机制作一探讨,以期能对今后军队流感疫情防控及降低死亡率提供帮助.

Pathogenic mechanisms of influenza virus and Staphylococcus aureus co-infection:research progress

Studies have shown that co-infection of influenza viruses with bacteria is an important cause of high mortality during the epidemic of influenza.There are at least 12 species of bacteria that have been reported to be able to co-infect with influenza.Among those species,co-infection with Staphylococcus aureus is not only the most common but also the most lethal.However,the pathogenesis of high mortality from co-infection with influenza virus/S.aureus remains elusive.In addition,co-infection of influenza virus/S.aureus can induce severe pneumonia.There is new evidence that influenza virus can reduce the host′s tolerance to pathogenic or inflammatory injury,and the two pathogens can also synergistically aggravate toxic effects on the host.Here,we review the mechanisms of severe mortality of influenza infection associated with S.aureus co-infections in order to contribute to prevention and control of influenza in the future.