昼夜节律在代谢调控中的作用

昼夜节律的产生和维持依赖于内源性生物钟调控系统,其遗传基础是由一系列生物钟基因(bmal1、clock、cry、per)和钟控基因(rev-erbα、rorα、dbp、tef、hlf等)组成的反馈调控环路.昼夜节律与机体代谢功能密切相关,参与机体糖、脂肪等营养物质的代谢过程.当饮食时间、睡眠障碍、作息颠倒等外源因素引起机体昼夜节律发生紊乱,可显著增加诱发代谢综合征的风险.该文将着重阐述昼夜节律及生物钟系统对机体代谢功能的影响,以及昼夜节律失调在诱发代谢综合征中的作用.

Function of circadian rhythms in regulation of metabolism

The circadian rhythm generated by the endogenous circadian clock system depends on the feedback loop composed of a series of core clock genes (bmal1, clock, cry and per) and clock controlled genes (rev-erbα, rorα, dbp, tef and hlf) .The circadian rhythm is closely related to the body metabolism , which plays important roles in the metabolic process of the major nutrients , such as glucose and fat .Circadian rhythm disorders caused by exogenous factors will significantly increase the risk of metabolic syndrome .This paper focuses on the effect of circadian rhythms on metabolism and their roles in regulating metabolic syndrome .