凝血酶原片段1+2、血浆D-二聚体对恶性肿瘤PICC相关性血栓形成的影响

目的通过检测恶性肿瘤患者PICC置管术后F1+2与D-Dimer的变化,探讨二者对PICC相关性血栓形成的影响。方法选取207例PICC置管的恶性肿瘤患者,采用酶联免疫吸附法(ELISA)分别检测F1+2及D-Dimer。根据是否发生PICC相关性血栓形成分为血栓形成组和对照组。结果 207例恶性肿瘤PICC相关性血栓形成的发生率为15.9%,F1+2与D-Dimer分别与临床分期有相关性(r=0.284、0.560,P0.05),与年龄、性别、肿瘤部位及放化疗无相关性(P0.05);与对照组相比,血栓组F1+2、D-Dimer均显著升高(P0.05);F1+2与D-Dimer呈正相关性(r=0.963,P=0.00);多因素Logistic分析显示F1+2、D-Dimer是恶性肿瘤PICC相关性血栓形成的独立危险因素。结论肿瘤患者F1+2及D-Dimer水平与临床分期有关,二者升高对PICC相关性血栓形成的早期诊断可能具有一定的临床价值。

Impact of prothrombin fragment 1 + 2 and D-Dimer on peripherally inserted central catheter associated thrombosis in cancer patients

Objective To detect and investigate the changes of F1 + 2 and D-Dimer in peripherally inserted central catheter(PICC) cancer patients,and their effect on PICC associated thrombosis.Methods A total of 207 cancer patients with PICC were selected and F1 + 2,D-Dimer were examined using Enzyme-linked immunoassay(ELISA).And they were divided into thrombosis group and control group according to PICC associated thrombosis occurrence condition.Results The incidence rate of PICC associated thrombosis in 207 malignant tumor was 15.9％.F1 + 2 and D-Dimer were correlated with clinical stage (r =0.284 & r =0.560,P ＜ 0.05),but was not correlated with age,sex,site of tumor and concurrent radiochemotherapy,respectively (P ＞ 0.05).Compared with control group,the levels of F1 + 2,D-Dimer were significantly increased in thrombosis group (P ＜0.05),and F1 +2 was positively correlated with D-Dimer(r =0.963,P =0.00).The multi-factor logistics analysis showed that F1 + 2,D-Dimer were independent risk factors for the PICC associated with thrombosis in cancer patients.Conclusion The levels of F1 + 2,D-Dimer were closely related with clinical staging,and the increase of F1 + 2,D-Dimer the clinical indicators for early diagnosis of PICC associated thrombosis.