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子宫内膜异位症患者腹腔镜术后应用促性腺激素释放激素类似物的效果观察
引用本文:张凤,赵绍杰,王金梅. 子宫内膜异位症患者腹腔镜术后应用促性腺激素释放激素类似物的效果观察[J]. 实用临床医药杂志, 2017, 21(19). DOI: 10.7619/jcmp.201719018
作者姓名:张凤  赵绍杰  王金梅
作者单位:江苏省无锡市妇幼保健院妇产科,江苏无锡,214000
基金项目:江苏省自然科学基金资助项目
摘    要:目的探讨子宫内膜异位症患者腹腔镜术后分别应用促性腺激素释放激素拮抗剂与孕三烯酮治疗的疗效差异。方法选取行腹腔镜手术治疗的子宫内膜异位症患者90例,对照组给予孕三烯酮治疗,观察组给予GnRHa治疗,比较2组患者治疗后的疗效、生殖激素水平、不良反应及复发情况。结果治疗后观察组总有效率为93.3%,显著高于对照组的71.1%(P0.05)。2组患者治疗后血清生殖激素水平(FSH、LH、E2、PRL)均较治疗前显著降低(P0.05),且观察组血清生殖激素水平降低更为显著(P0.05)。2组治疗后不良反应发生率比较,差异无统计学意义(P0.05)。2组患者均随访1~2年,其中对照组随访时间内复发9例,观察组随访时间内复发3例,差异有统计学意义(P0.05)。结论子宫内膜异位症患者腹腔镜术后应用GnRHa更加安全、有效,复发率更低。

关 键 词:子宫内膜异位症  腹腔镜  促性腺激素释放激素拮抗剂  疗效

Effect of gonadotropin releasing hormone analogues after laparoscopic surgery on treatment of patients with endometriosis
ZHANG Feng,ZHAO Shaojie,WANG Jinmei. Effect of gonadotropin releasing hormone analogues after laparoscopic surgery on treatment of patients with endometriosis[J]. Journal of Clinical Medicine in Practice, 2017, 21(19). DOI: 10.7619/jcmp.201719018
Authors:ZHANG Feng  ZHAO Shaojie  WANG Jinmei
Abstract:Objective To investigate the effect of gonadotropin-releasing hormone antagonist (GnRHa) and gestrinone after laparoscopic surgery in patients with endometriosis.Methods Ninety patients with endometriosis who underwent laparoscopic surgery in our hospital were selected as the subjects.The patients in the control group were treated with gestrinone,while the observation group received GnRHa treatment.Treatment efficacy after treatment,reproductive hormone levels,adverse reactions and recurrence condition were compared.Results The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant (93.3% vs.71.1%,P < 0.05).The levels of serum reproductive hormone (FSH,LH,E2,PRL) in the two groups were significantly lower than treatment before (P < 0.05),and the levels of FSH,LH in the observation group were significantly lower than the control group (P < 0.05).The incidence of adverse reactions showed no significant difference (P > 0.05).The patients in the two groups were followed up for 1 to 2 years.Among them,9 cases had recurrence in the control group and 3 cases in the observation group,and significant difference was seen between the two groups (P <0.05).Conclusion GnRHa therapy is more safe,and effective and has lower relapse rate.
Keywords:endometriosis  laparoscopy  gonadotropin releasing hormone antagonists  efficacy
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