| 异丙酚对大鼠肺缺血/再灌注损伤的保护作用 |
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| 引用本文： | 李锁北,阮溦,徐军美,李艳,吕志平. 异丙酚对大鼠肺缺血/再灌注损伤的保护作用[J]. 中国医师杂志, 2009, 11(7): 1186-1188 |
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| 作者姓名： | 李锁北 阮溦 徐军美 李艳 吕志平 |
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| 作者单位： | 中南大学湘雅二医院麻醉科,湖南,长沙,410011;海南省人民医院麻醉科; |
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| 摘 要： | Objective To study the protective effects of propofol against ischemia/reperfusion injury in rat lung. Methods Rat model of pulmonary ischemia/reperfusion injury was used in this study. Rats were randomly divided into three groups, including sham opera-tion group (group A), iachemia/reperfusion group (group B) and propofol group (group C), 15 rats in each group. The concentration of tumor necrosis factor -α and interleukin-6 in bronchoalveolar lavage fluid (BALF) were measured by enzyme linked immunosorbent assay (ELISA). Then blood gas analysis, lung wet/dry (W/D) weight ratio were detected in each group. Results Propofol could significantly improve PaO2, reduce the W/D value and the contents of TNF-α and IL-6 in BALF. Conclusion Propofol effectively suppressed the pro-duction and release of inflammatory cytokine, therefore it can protect the lung from isehemia/reperfusion injury.
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| 关 键 词： | 二异丙酚/药理学 肺/血液供给/病理生理学/药物作用 缺血/预防和控制 再灌注损伤/预防和控制 |
The protective effect of propofol on pulmonary ischemia/reperfusion injury |
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| Keywords: | PropofoL/PDLung/BS/PP/DEIschemia/PCReperfusion injury/PC |
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