阿魏酸钠对慢性应激抑郁模型大鼠抗抑郁作用的实验研究

Objective To measure the antidepressive activity of sodium ferulate (SF) in chronic unpre-dictable mild stress (CUMS) rat model of depression. Methods Male Sprague-Dawley (SD) strain rats weighing 220～280g were divided into six matched groups (n=11 in each group ) based on their sucrose consumption in preliminary tests (1% sucrose solution) : control, CUMS(model) , CUMS + fluoxetine (FLU) ( positive control), and treatment ( CUMS + SF) groups. The rats in model group were exposed to CUMS for 28 days;the rats in posi-ly) for 28 days;the animals in treatment groups were exposed to CUMS and received administration of SF (20,40, care and received ip administration of normal saline simultaneously. The rats except control were housed separately in different rooms during the duration of the stress procedure. The rat model of depression was established by expo-sing to an unpredictable sequence of stressors;the body weight,food intake and fluid consumption were measured ;the behaviors were examined by open field and forced-swimming tests. A representative sections cutting across hip-pocampal area of the rats in the six groups were examined by light microscopy. Results The rat model of depres-sion has been established successfully at 28th day. The results showed that chronic ip administration of SF signifi-cantly reversed the effects of CUMS on the body weight gain,the consumption of sucrose solution,the squares cross-ing and rearing in open field test and the immobility time during forced-swimming test of the rats [(88.06±7.83) g vs. (77.15±14.66 )g;(66.33±3.03)g vs. (40.75±6.05)g;(25.10±4,90) times vs. (18.20±2.00) times, (6.60±1.20 ) times vs. (3.20±0.60) times ;(117.30±7.22) s vs. (148.10±8.25)s], the values of P were 0.0425,0.0087,0.0409,0.0317,0.0025 respectively,and also partially reversed the effects of CUMS on his-topathology of hippoeampus. Conclusion SF possesses potent antidepressant-like activity,and the antidepressant-like action may result from its neuroprotective effect.

Antidepressant-like activity of sodium ferulate measured by chronic experimental method in rat model of depression