硝酸甘油对大鼠重症急性胰腺炎ET/NO、TXA2/PGI2的影响 |
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引用本文: | 秦春宏,张春礼,张树友.硝酸甘油对大鼠重症急性胰腺炎ET/NO、TXA2/PGI2的影响[J].中国医师杂志,2009,11(7):1188-1190. |
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作者姓名: | 秦春宏 张春礼 张树友 |
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作者单位: | 南华大学附属第二医院普外科,湖南,衡阳,421001; |
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基金项目: | 衡阳市科技局2006年基础研究计划项目资助 |
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摘 要: | Objective To explore the effect of nitroglycerin on ET/NO, TXA2/PGI2 and pancreas pathomorphology changes in severe acute pancreatitis (SAP) rats. Methods Sixty SD rats were random divided into five groups, including control group (A group, n = 12) and experimental group(B,C,D and E group, n = 12). The SAP was induced by injection of 5% sodium taurocholate through retrograde common biliopancreatic ducts via duodenal papilla with epidural catheter. Group C, D and E were intravenously injected with nitroglycerin 0.5μg/kg/min,1μg/kg/min and 2μg/min in 30 min respectively, and group A and B was injected with Sodium Chloride 0.5ml. The indexes of changed pathomorphology and ET/NO, TXB2/6-keto-PGF1a, were determined at the 6th and 12th hour after operations, respectively. Results The specimen data of the 6th and 12th hour displayed that the indexes of changed pathomorphology, ET, ET/NO, TXB2, and TXB2/6-keto-PGF1a of the group C,D and E degraded respectively, compared to group B(P < 0.05). Conclusion The nitroglycerin could degrade ET, ET/NO,TXA2 and TXA2/PGI2, improve the microcirculation of pancreas, and delay the pathological inflammation change in SAP rats.
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关 键 词: | 硝酸甘油/药理学 胰腺炎 急性坏死性/药物疗法/代谢 内皮缩血管肽类/代谢 一氧化氮/代谢 血栓烷A2/代谢 依前列醇/代谢 胰腺/药物作用/病理学 |
The effect of nitriglycerin on ET/NO and TXA2/PGI2 in severe acute pancreatitis rats |
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Abstract: | |
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Keywords: | Nitroglycerin/PDPancreatitisacute necrotizing/DT/MEEndothelins/MENitric oxide/METhromboxane A2/MEEpoprostenol/MEPancreas/DE/PA |
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