利培酮、奥氮平、喹硫平对首发精神分裂症患者认知功能和社会功能的影响 |
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引用本文: | 宁布,许明智,林勇强,全东明,林海程,冯梅珍,刘武汉,贾福军. 利培酮、奥氮平、喹硫平对首发精神分裂症患者认知功能和社会功能的影响[J]. 中华行为医学与脑科学杂志, 2009, 18(7): 710-712. DOI: 10.3760/cma.j.issn.1674-6554.2009.08.014 |
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作者姓名: | 宁布 许明智 林勇强 全东明 林海程 冯梅珍 刘武汉 贾福军 |
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作者单位: | 广东省人民医院,广东省医学科学院,广东省精神卫生研究所,广州,510120; |
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基金项目: | 广东省医学科学研究基金 |
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摘 要: | Objective To compare the influence of risperidone,olanzapine and quetiapine on cognitive function and social functioning in patients with first-episode schizophrenia. Methods Total of 61 patients diag-nosed with first-episode schizophrenia were evaluated on efficacy, social functioning and cognitive function in 6 weeks,and 42 healthy controls were given a same cognitive function assessment. Results Mean doses were 4.2 mg/d, 18.6 mg/d,and 561.3 mg/d for risperidone,olanzapine,and quetiapine respectively. The mean change from baseline to end point in PANSS and PSP total score in three groups were 19.7±20.2,20.2±21.0,15.8±19.4 and 7.8±16.3,8.2±15.2,6.8±14.8 respectively. Significant improvements from baseline to end point were observed on the CGI-S scale in the three treatment groups (P<0.05). All the patients before treatment compare with normal controled group in cognitive function measurement such as WCST,TMT and WMS,were sig-nificant differences (P<0.05). Executive function and memory after treatment had not improved in risperidone and quetiapine group, while three indices of WCST has improved in olanzapine group (P<0.05) ,rate of motion percep-tion,attention and capacity of concept conversion had be improved in all groups (P<0.05). The most frequently adverse events reported in Risperidone group was EPS which were mild in severity,in olanzapine and quetiapine group,the most frequently adverse events were somnolence. Conclusion Risperidone,olanzapine and quetiapine can improve part of cognitive function and social functioning in patients with first-episode schizophrenia, and the effects of them were similar.
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关 键 词: | 首发精神分裂症 认知功能 社会功能 |
Influence of three antipsychotics on cognitive function and social functioning in patients with first-episode schizophrenia |
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Abstract: | |
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Keywords: | First-episode schizophreniaCognitive functionSocial functioning |
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