| Abstract: | Objective: To observe the influence of acupuncture on the cognitive function and serum sCD40 L of patients with subcortical ischemic vascular disease(SIVD), to explore the relationship between cognitive function and the level of serum sCD40 L of patients with SIVD and to provide new ideas for clinical treatment.Methods: Sixty cases of SIVD were randomly divided into acupuncture treatment group and nimodipine group, 30 cases of each group.The acupuncture treatment group took the acupoints of Baihui(DU20), Renzhong(DU26), Fengfu(DU16), Fengchi(GB20), Neiguan(PC6), Shenmen(HT7), Hegu(LI4) and Taichong(LR3), and the needles were kept 30 min each time.The matched group took oral nimodipine 30 mg for three times per day.Both of the groups were treated for 4 weeks as a course and it was 2 courses totally.Cognitive function(MoCA score) and serum sCD40 L level of patients before and after the treatment were observed.Results: After four weeks' treatment, the patients in the treatment group got a significant decreasing in serum sCD40L(P0.01), no obvious changes were observed in the control group(P0.05).Cognitive function in patients was improved notably.After 8 weeks' treatment, the serum sCD40 L levels of patients in the two groups were significantly decreased(P0.01), and the curative effect of the treatment group was better than the control's.Cognitive function in patients was improved notably(P0.05).Conclusion: Acupuncture can significantly reduce the content of serum sCD40 L of patients with SIVD and improve their cognitive function. |
