| Abstract: | Objective: To observe the clinical therapeutic efficacy of electroacupuncture combined with paroxetine on mild or moderate depression and the effect of electroacupuncture on the side effects of paroxetine.Methods: Fifty-five patients with mild or moderate depression were randomly divided into group A(paroxetine group, 29 patients) and group B(electroacupuncture combined with paroxetine group, 26 patients).Therapeutic periods for the two groups were 6 weeks.Hamilton Depression Rating Scale for Depression(HAMD) and Rating Scale for Side Effects(SERS) were used to evaluate the efficacy before and after treatment in weeks 1, 2, 4 and 6.Results: After 2 weeks of treatment, HAMD scores for group A were significantly different compared with the beginning of the research(P0.05); HAMD scores for group B after 1 week of treatment were significantly different compared with the beginning of the research(P0.05); after 6 weeks of treatment, there were no significant differences between group A and group B(P0.05).Total effective rate of HAMD for group A was 71.4%, and total effective rate of HAMD for group B was 88%.Total effective rate of HAMD was significantly different between the two groups(P0.05).SERS scores for group A were not different compared with the beginning of the research(P0.05); SERS scores for group B were different compared with the beginning of the research for the fourth week(P0.05); SERS scores for group B were significantly different compared with the beginning of the research for the sixth week(P0.01).Conclusion: Electroacupuncture could improve paroxetine's efficacy on mild or moderate depression; at the same time, electroacupuncture combined with paroxetine could significantly decrease the side effects of paroxetine. |
