| Abstract: | Objective: Autophagy is a major catabolic pathway, by which mammalian cells degrade and macromolecules and organelles recycle, required for beclin-1 and related with the energy.Adenosine1 receptors(A1R) and adenosine 2a receptors(A2aR) play roles in regulating myocardial oxygen consumption, involving energy metabolism.In this study, the impacts of electroacupuncture(EA) on the protein expression of beclin-1, A1 R, and A2 aR in the heart of the rats with myocardial ischemia(MI) were investigated and the mechanisms were explored.Methods: The rats were divided randomly into 3 groups: control group, model group and EA group.EA was applied at Neiguan(PC6) with 2/15 Hz and 1 mA current in the EA group, once a day for 7 d.Results: Results showed that EA could promote the recovery of myocardium, reverse the S-T segment change, decrease serum CK, CK-MB, and LDH levels, and increase the expression of beclin-1 and A2 aR, but not A1 R in the MI tissue.Conclusion: The results of the study implied that EA regulated the energy metabolism and promoted the removal of necrotic myocardial cells through autophagy, which may serve as one possible mechanism to enhance the recovery of ischemic myocardium. |
