| Abstract: | Objective: Rosiglitazone has been used to reduce blood sugar of type 2 diabetes mellitus(T2DM) patients for years.However, its side effect of weight-gain restricts its application in clinic.The aim of this study was to investigate if acupuncture, an effective approach for weight-loss can reduce the side effect of rosiglitazone.Methods: Male SD adult rats were fed with high-fat highsugar food for one month when insulin resistance occurred, then were given streptozotocin(STZ, 35 mg/kg, intraperitoneal injection).These rats developed T2DM-like disease after XXX days application with STZ.The T2 DM animal models were treated by rosiglitazone for 30 d.Body weight and food intake were examined every 3 days during the medication.The animals were divided to XX group and XXX group.Zusanli and Neiting acupoints were selected in the weight-gain group for electroacupuncturing(2/15 Hz at an intensity level of 2 mA).Results: The results showed that the body weight and food intake of T2 DM rats were much higher than those of the model group, whereas 30-day treatment with rosiglitazone combined with acupuncture reduced body weight and food intake.Conclusion: In conclusion, acupuncture could significantly reduce the side effect induced by rosiglitazone.The mechanisms are under investigated in our ongoing research. |
