Dopexamine and norepinephrine versus epinephrine on gastric perfusion in patients with septic shock: a randomized study [NCT00134212] |
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| Authors: | Philippe Seguin Bruno Laviolle Patrick Guinet Isabelle Morel Yannick Mallédant and Eric Bellissant |
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| Institution: | (1) Service de R?animation Chirurgicale INSERM U620, H?pital de Pontchaillou, Universit? de Rennes 1, Rennes, France;(2) Centre d'Investigation Clinique INSERM 0203, Unit? de Pharmacologie Clinique, H?pital de Pontchaillou, Universit? de Rennes 1, Rennes, France;(3) Laboratoire des Urgences & R?animations, H?pital de Pontchaillou, Universit? de Rennes 1, Rennes, France |
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| Abstract: | Introduction Microcirculatory blood flow, and notably gut perfusion, is important in the development of multiple organ failure in septic
shock. We compared the effects of dopexamine and norepinephrine (noradrenaline) with those of epinephrine (adrenaline) on
gastric mucosal blood flow (GMBF) in patients with septic shock. The effects of these drugs on oxidative stress were also
assessed. |
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