| 慢性非细菌性前列腺炎/慢性骨盆疼痛综合征患者外周血Th_1/Th_2淋巴细胞比值的免疫学研究 |
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| 引用本文： | 刘大标,王洪珍,成晓青,顾红兵,孟子裕.慢性非细菌性前列腺炎/慢性骨盆疼痛综合征患者外周血Th_1/Th_2淋巴细胞比值的免疫学研究[J].实用医技杂志,2007,14(30):4131-4132. |
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| 作者姓名： | 刘大标 王洪珍 成晓青 顾红兵 孟子裕 |
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| 作者单位： | 1. 江苏大学附属第四医院,江苏,镇江,212001
2. 江苏大学附属第一医院,江苏,镇江,212001 |
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| 摘 要： | 目的:探讨慢性非细菌性前列腺炎/慢性骨盆疼痛综合征(CAP/CPPS)患者外周血Th1/Th2细胞分布的变化情况,了解其在CAP/CPPS发病过程中的意义。方法:采用流式细胞学检测40例CAP/CPPS患者和20例健康体检者外周血CD3+CD8-T细胞内细胞因子干扰素γ(IFN-γ)和白细胞介素(IL-4)的表达。结果:与正常对照相比,Ⅲa型、Ⅲb型CAP/CPPS患者的Th1细胞数均升高,Th1/Th2比值升高,差异有显著性(P<0.05),Th2细胞数差异无显著性(P>0.05)。结论:CAP/CPPS患者Th1/Th2平衡失调,Th1型免疫反应模式占优势状态,提示Th1细胞在CAP/CPPS的疾病发生中可能起重要作用。
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| 关 键 词： | 慢性非细菌性前列腺炎/慢性骨盆疼痛综合征 Th_1/Th_2 流式细胞仪 |
| 文章编号： | 1671-5098（2007）30-4131-02 |
| 收稿时间： | 2007-07-20 |
Detection of Peripheral Blood Th1/Th2 Cell Ratio in Patients with Chronic Abacterial Prostatitis/Chronic Pelvic Pain Syndrome |
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| LIU Da-biao,WANG Hong-zhen,CHENG Xiao-qing,GU Hong-bing,MENG Zi-yu.Detection of Peripheral Blood Th1/Th2 Cell Ratio in Patients with Chronic Abacterial Prostatitis/Chronic Pelvic Pain Syndrome[J].Journal of Practical Medical Techniques,2007,14(30):4131-4132. |
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| Authors: | LIU Da-biao WANG Hong-zhen CHENG Xiao-qing GU Hong-bing MENG Zi-yu |
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| Affiliation: | 1. The Affiliated Fourth Hospital of Jiangsu University, Zhenfiang , Jiangsu 212001, China ; 2. The Affiliated First Hospital of Jiangsu University, Zhenfiang, Jiangsu 212001, China |
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| Abstract: | Objective To investigate the change of peripheral Th1/Th2 cells in patients with CAP/CPPS and evaluate its in the etiology of CAP/CPPS.Methods Interferon-γ(IFN-γ) and interleukin-4(IL-4) secreted by CD3+CD8-T cells were detected by flow cytometry in 40 patients with CAP/CPPS and 20 healthy volunteers.Results Compared with control group,peripheral Th1 cells were significantly increased in patients with Ⅲa and Ⅲb CAP/CPPS.The Th1/Th2 cells ratio was apparently creased(P<0.05),while Th2 cells was not different from that in the control(P>0.05).Conclusion There is a Th1/Th2 imbalance in CAP/CPPS patients with an increase of Th1 type cytokines,Th1 cell may play an importantrole in the pathogenesis of CAP/CPPS. |
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| Keywords: | CAP/CPPS Th1/Th2 flow cytometry |
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