中重度急性有机磷农药中毒气道开放时机与预后的相关性研究

目的研究气道开放时机与中重度急性有机磷农药中毒(AOPP)患者预后的相关性。方法选择中重度AOPP患者96例,随机分为治疗组(56例)、对照组(40例),治疗组在常规治疗基础上预防性提前开放气道,对照组在常规治疗基础上,只有当发生呼吸衰竭,需要机械通气时才开放气道。结果与对照组比较,治疗组ARDS、吸入性肺炎、呼吸衰竭等并发症明显减少(P<0.01,P<0.05),病死率显著降低(P<0.01).住院天数缩短(P<0.05)。结论在中重度AOPP救治中,预防性气道开放能改善患者预后。降低病死率,缩短住院天数,值得推广。

Relationship between the timing of airway opening and prognosis in moderate-severe acute organophosphorus pesticide poisoning patients

Objective To research relationship between the timing of airway opening and prognosis of patients with moderate-severe acute organophosphorus pesticide poisoning(AOPP).Methods 96 patients with moderate-severe AOPP were randomly divided into therapy group and control group.In thera- py group,the airways of patients preventively opened in advance besides the routine treatment.In control group,the airways of patients were opened only when the respiratory failure occurred and the patients nee- ded mechanical ventilation.Results Compared with control group,the complications such as ARDS(P<0.01),aspiration pneumonia(P<0.01)and respiratory failure(P<0.05)etc.decreased obviously, mortality was less(P<0.01),the days in hospital(P<0.05)was shorter in therapy group.Conclu- sions Preventive airway opening of the patients with moderate-severe AOPP can improve prognosis of patients,decrease mortality,shorten the days in hospital,should be widely applied.