| 小鼠匹罗卡品癫癇模型中嗅球神经变性的FJC染色评价 |
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| 引用本文： | 王莲,魏玲,张丽萍.小鼠匹罗卡品癫癇模型中嗅球神经变性的FJC染色评价[J].华南国防医学杂志,2011,25(5):383-385. |
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| 作者姓名： | 王莲 魏玲 张丽萍 |
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| 作者单位： | 成都军区昆明总医院神经内科,云南昆明,650032 |
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| 摘 要： | 目的 探测小鼠匹罗卡品癫癇模型中嗅球结构中神经元变性情况,了解嗅球结构在慢性颞叶癫癇发生中的病理变化及癫癇反复发作的神经基础.方法 雄性昆明小鼠6只(对照组3只,匹罗卡品处理组3只).在癫癇持续状态后12h处死处理组小鼠.在嗅球水平切制冠状切片,行Fluoro-Jade C(FJC)染色,在荧光显微镜下观察FJC阳性细...
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| 关 键 词： | Fluoro-Jade C 癫癇 匹罗卡品 神经变性 |
Fluoro-Jade C Staining in Neurodegeneration Assessment in the Olfactory Bulb of Pilocarpine-treated Mice |
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| WANG Lian,WEI Ling,ZHANG Li-ping.Fluoro-Jade C Staining in Neurodegeneration Assessment in the Olfactory Bulb of Pilocarpine-treated Mice[J].Military Medical Journal of South China,2011,25(5):383-385. |
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| Authors: | WANG Lian WEI Ling ZHANG Li-ping |
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| Institution: | WANG Lian,WEI Ling,ZHANG Li-ping.Department of Neurology,Kunming General Hospital of Chengdu Military Command,Kunming Yunnan 650032,China |
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| Abstract: | Objective To detect the degenerative neurons in the olfactory bulb of pilocarpine-treated mice and understand pathological changes of the olfactory bulb and the neural basis of recurrent seizure of chronic epilepsy. Methods Six male adult Kunming mice were divided into pilocarpine-treated group(n=3) and control group(n=3).Pilocarpine-treated mice were sacrificed at 12 hours after status epilepticus.Brain coronal sections in the olfactory bulb levels were subject to Fluoro-Jade C(FJC) staining and examined u... |
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| Keywords: | Fluoro-Jade C Epilepsy Pilocarpine Neurodegeneration |
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