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| CTLA-4基因单倍型与吸毒合并HIV感染的相关性研究 | |
| 引用本文： | 刘莹,刁波,申元英,周芳,冯勇,罗凡,侯炜. CTLA-4基因单倍型与吸毒合并HIV感染的相关性研究[J]. 华南国防医学杂志, 2011, 25(5): 399-401 |
| 作者姓名： | 刘莹 刁波 申元英 周芳 冯勇 罗凡 侯炜 |
| 作者单位： | 1. 广州军区武汉总医院医学检验科,湖北武汉,430070 2. 广州军区武汉总医院医学医学实验科,湖北武汉,430070 3. 大理学院公共卫生学院 4. 武汉大学医学病毒学研究所 |
| 基金项目： | 国家自然科学基金项目(30972754) |
| 摘 要： | 目的 研究细胞毒T淋巴细胞相关抗原4(cytotoxic T lymphocyte associated antigen-4,CTLA-4)基因外显子1的49位点和启动子-318位点单倍型与吸毒合并HIV感染的相关性.方法 采用序列特异性引物聚合酶链反应(polymeriase chain reaction with ... |
| 关 键 词： | 吸毒并HIV感染 细胞毒T淋巴细胞相关抗原4 基因多态性 单倍型 |
Association between Cytotoxic T Lymphocyte-associated Antigen 4 Gene Haplotype and Drug Abuse with HIV Infection |
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| LIU Ying,DIAO Bo,SHEN Yuan-ying,ZHOU Fang,FENG Yong,LUO Fan,HOU Wei. Association between Cytotoxic T Lymphocyte-associated Antigen 4 Gene Haplotype and Drug Abuse with HIV Infection[J]. Military Medical Journal of South China, 2011, 25(5): 399-401 | |
| Authors: | LIU Ying DIAO Bo SHEN Yuan-ying ZHOU Fang FENG Yong LUO Fan HOU Wei |
| Affiliation: | LIU Ying,DIAO Bo,SHEN Yuan-ying,ZHOU Fang,FENG Yong,LUO Fan,HOU Wei.Department of Clinical Laboratory,Wuhan General Hospital of Guangzhou Military Command,Wuhan Hubei 430070,China |
| Abstract: | Objective To investigate the association between the haplotype of cytotoxic T lymphocyte-associated antigen 4(CTLA-4) and drug abuse with HIV infection. Methods The A+49G transition polymorphism at position 49(exon 1) and C-318T transition polymorphism at position 318 in the promoter of the CTLA-4 gene were determined by polymerase chain reaction with sequence specific primers(PCR-SSP) method in 24 drug abusers,41 drug abusers with HIV infection and 204 healthy controls. Results Compared with the control gr... |
| Keywords: | Drug abuse with HIV infection Cytotoxic T lymphocyte-associated antigen Gene polymorphism Haplotype |
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