| 肿瘤转移抑制基因nm23-H1 mRNA在人卵巢癌中的表达 |
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| 引用本文： | 周晓宁,陈晓东,王昭梅,沙金燕,崔英,顾青,姜海燕.肿瘤转移抑制基因nm23-H1 mRNA在人卵巢癌中的表达[J].第二军医大学学报,1999,20(10):743-745. |
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| 作者姓名： | 周晓宁 陈晓东 王昭梅 沙金燕 崔英 顾青 姜海燕 |
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| 作者单位： | 1. 第二军医大学长海医院妇产科,上海,200433
2. 广州军区广州总医院病理科 |
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| 摘 要： | 通过检测人卵巢癌标本中肿瘤转移抑制基因ｎｍ２３－Ｈ１ｍＲＮＡ的表达，了解其临床意义及其与预防的关系，方法应用原位杂交技术检测４３例人卵巢癌标本中ｎｍ２３－Ｈ１ｍＲＮＡ的表达水平。结果ｎｍ２３－ｈ１ｍＲＮＡ的表达水平与卵巢癌的病理组织学类型无关；与患者术时有淋巴结或大网膜转移呈负相关，且转移灶的阳性表达率低于原发灶。结论ｎｍ２３－Ｈ１基因在人卵巢癌的扩散和转移过程中可能发挥着抑制作用，它在卵巢癌组织
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| 关 键 词： | 卵巢肿瘤 肿瘤转移抑制基因 原位杂交 |
Expression of tumor metastasis suppressor gene nm23-H1 mRNA in human ovarian carcinomas |
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| Zhou Xiaoning,Chen Xiaodong,Wang Zhaomei,Sha Jinyan,Cui Ying,Gu Qing,Jiang Haiyan.Expression of tumor metastasis suppressor gene nm23-H1 mRNA in human ovarian carcinomas[J].Academic Journal of Second Military Medical University,1999,20(10):743-745. |
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| Authors: | Zhou Xiaoning Chen Xiaodong Wang Zhaomei Sha Jinyan Cui Ying Gu Qing Jiang Haiyan |
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| Institution: | Zhou Xiaoning, Chen Xiaodong, Wang
Zhaomei, Sha Jinyan, Cui Ying, Gu Qing, Jiang Haiyan
(Department of Obstetrics and Gynecology, Changhai Hospital, Second Military Medical
University, Shanghai, 200433) |
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| Abstract: | Objective: To detect the expression of tumor metastasis suppressor gene nm23 H1 mRNA in human ovarian carcinomas, and to evaluate its clinic value as well as its relationship with prognosis. Methods: The expression of nm23 H1 mRNA was detected in 43 cases of human ovarian carcinomas by means of in situ hybridization. Results: The expression of nm23 H1 mRNA did not statistically correlated with histologic types of ovarian carcinomas ( P >0.05); there was an inverse relationship between nm23 H1 mRNA level and those cases with metastasis foci both in lymph nodes and in the great omentum( P <0 05); positive rate of nm23 H1 mRNA was higher in primary than in metastatic foci( P <0.05). Conclusions: nm23 H1 gene may play an important role in suppressing metastasis of ovarian carcinomas. The expression of nm23 H1 gene in ovarian cancer tissues may serve as one of assessable factors for prognosis in ovarian carcinoma. |
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| Keywords: | ovarian heoplasms tumor metastasis suppressor gene in situ hybridization |
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