| 持续动态压应力对实验性骨折愈合的影响 |
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| 引用本文： | 任可,张春才,许硕贵,唐昊,康庆林,高堂成,张雪松.持续动态压应力对实验性骨折愈合的影响[J].第四军医大学学报,2004,25(1):41-45. |
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| 作者姓名： | 任可 张春才 许硕贵 唐昊 康庆林 高堂成 张雪松 |
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| 作者单位： | 第二军医大学长海医院骨科,上海,200433;第二军医大学长海医院骨科,上海,200433;第二军医大学长海医院骨科,上海,200433;第二军医大学长海医院骨科,上海,200433;第二军医大学长海医院骨科,上海,200433;第二军医大学长海医院骨科,上海,200433;第二军医大学长海医院骨科,上海,200433 |
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| 摘 要： | 目的:探讨持续动态压应力环境对实验性骨折愈合的影响及机制. 方法:对25只家犬股骨干造成双侧横断截骨,随机选一侧天鹅记忆接骨器(SMC)固定,对侧以髓内钉固定作为对照,分别在术后7, 14, 21, 28和49 d时,在骨折间隙内取材,行组织学观察及Ⅸ型胶原和骨钙素mRNA的Northern blot杂交. 结果:组织学观察和Northern blot结果均表明,SMC固定下骨折间隙内愈合组织的软骨形成速度明显快于对照组,软骨内成骨也得以强化. 结论:镍钛形状记忆合金接骨器产生的持续动态纵向压应力有利于骨折愈合.
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| 关 键 词： | 骨折愈合 骨折固定术 生物力学 分子生物学 形状记忆合金 |
| 文章编号： | 1000-2790(2004)01-0041-05 |
| 修稿时间： | 2003年7月8日 |
Effect of continuous dynamic compressive stress on femoral fractures healing in dogs |
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| REN Ke,ZHANG Chun Cai,XU Shuo Gui,TANG Hao,KANG Qing Lin,GAO Tang Cheng,ZHANG Xue Song.Effect of continuous dynamic compressive stress on femoral fractures healing in dogs[J].Journal of the Fourth Military Medical University,2004,25(1):41-45. |
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| Authors: | REN Ke ZHANG Chun Cai XU Shuo Gui TANG Hao KANG Qing Lin GAO Tang Cheng ZHANG Xue Song |
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| Institution: | REN Ke,ZHANG Chun Cai,XU Shuo Gui,TANG Hao,KANG Qing Lin,GAO Tang Cheng,ZHANG Xue Song Department of Orthopaedics,Changhai Hospital,Second Military Medical University,Shanghai 200433,China |
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| Abstract: | AIM: To explore the effect and mechanism of continuous dynamic pressure stress on femoral fractures healing in dogs. METHODS: Bilateral femoral of 15 adult dogs were osteotomized in the middle and then 1 femur was randomly internal fixed with swan like memory connector (SMC) while the contralateral side fixed with Kuntscher intramedullary nails. Five animals in each group were sacrificed at 7, 14, 21, 28, 49 d after operation. Samples from the fracture gaps were obtained and histological and molecular biological techniques (expression of the mRNA of the cartilage specific collagen IX and osteocalcina marker for mature osteoblasts) were employed. RESULTS: In terms of histology and molecular biology, the chondrogenesis in the fracture gap continued for shorter period and the enchondral ossificassion were strengthened in fractures fixed with SMC. CONCLUSION: The persistent dynamic longitudinal pressure stress produced by SMC may contribute to the process of healing of long bone. |
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| Keywords: | fracture healing internal fixation biomechanism molecular biology shape memory alloy |
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