国产长春瑞滨联合阿霉素治疗转移性乳腺癌的临床观察

目的：观察国产长春瑞滨（盖诺）联合阿霉素方案治疗转移性乳腺癌的临床疗效。方法：运用国产长春瑞滨（25mg/m^2 iv dl,5)加阿霉素（40mg/m^2iv dl)治疗转移性乳腺癌28例，结果：取得CR4例，PR13例，总有效率（CR＋PR）达60．7％；主要毒副反应为白细胞减少，发生率为92．8％，其中Ⅲ-Ⅳ度骨髓抑制占64．2％，结论：国产长春瑞滨加阿霉素方案对转移性乳腺癌疗效明确，血骨髓抑制明显。

Combination chemotheraphy with vinorelbine and doxorubicin intreatment of metastatic breast cancer

ve: To study the effect of combination chemotherapy of Vinorelbine and Doxorubicin in the treatment of metastatic breast cancer. Metheds:28 patients of metastatic breast cancer were treated with Vinorelbine 25 mg/m2 iv for day 1 and 5, and Doxorubicin 40mg/m2 iv for day 1. Results: complete response in 4 patients and parial response in 13 patients were observed with an overall response rate of 60.7% . Leukopenia was the most frequent toxicity(92. 8% ) and the grade 3, grade 4 leukopnia were totally present in 64.2% . Conclusions :The study demonstrated that regimen was effective in the treament of metastatic breast cancer. It should be gived attention to leukogenia.