左旋精氨酸对犬实验性冬眠心肌的保护作用

目的 :观察左旋精氨酸对冬眠心肌功能、代谢与结构的影响。方法 :30只犬短期冬眠心肌模型随机分为 3组 :A组 （n=14）灌注生理盐水 ;B组 （n=8）灌注左旋精氨酸 ;C组 （n=8）灌注 L- MNNA。结果 :3组间左心室舒张末期压、血乳酸、ATP含量及电镜下结构改变差异显著。左旋精氨酸组明显优于其他两组。结论 :左旋精氨酸可改善冬眠心肌、代谢与功能结构。

Protective effect of L-arginine on hibernating myocardium in dog-model

AIM:To investigate L-arginine(L-arg) influcence on function,metabolic and structure of myocardium. METHODS:The thirty dogs which dog-models under short-hibernating myocardium was established were randomly divided into three groups. A (control)group(n=14) perfusing 9 g/L NaCl, B group(n=8) perfusing l-arg, C group(n=8) perfusing L-MNNA. RESULTS:LVEDP,Lactate release,ATP content and ultrastructure have remarkable difference among three groups. L-arg group outstandingly was superior to other groups.CONCLUSION:L-arg can improve the function,metabolic and structure of hibernating myocardium.