| 盐酸莫西沙星搽剂的制备及质量控制 |
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| 引用本文： | 隋海超,崔芹芹,孙秀芹.盐酸莫西沙星搽剂的制备及质量控制[J].齐鲁药事,2013,32(1):32-33. |
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| 作者姓名： | 隋海超 崔芹芹 孙秀芹 |
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| 作者单位： | 鲁南制药集团股份有限公司,山东,临沂276006 |
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| 摘 要： | 目的制备盐酸莫西沙星搽剂并建立其质量控制方法。方法以盐酸莫西沙星为主药制备搽剂;采用高效液相色谱法测定其中主药含量,并考察其稳定性。结果盐酸莫西沙星检测浓度的线性范围为6.0～36μg.mL-1(r=0.999 9),平均回收率为99.81%(RSD=0.506%,n=9)。结论本制剂制备工艺简便可行,质量稳定可控。
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| 关 键 词： | 盐酸莫西沙星搽剂 制备 质量控制 高效液相色谱法 |
Preparation and quality control of Moxifloxacin Hydrochloride Liniment |
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| SUI Hai-chao
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CUI Qin-qin
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SUN Xiu-qin.Preparation and quality control of Moxifloxacin Hydrochloride Liniment[J].qilu pharmaceutical affairs,2013,32(1):32-33. |
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| Authors: | SUI Hai-chao CUI Qin-qin SUN Xiu-qin |
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| Institution: | (Lunan Pharmaceutical Group Co.,Ltd.,Linyi 276006,China) |
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| Abstract: | Objective To prepare Moxifloxacin Hydrochloride Liniment and establish a method for its quality control.Methods The Moxifloxacin Hydrochloride Liniment was prepared with moxifloxacin as chief agent,and the content was determined by HPLC and the stability was investigated.Results There was a good linear relationship within the concentration range of 6.0~36 μg·mL-1(r=0.999 9),and the average recovery rate was 99.55%(RSD=0.98%,n=6).Conclusion The preparation technology for liniment was simple and feasible and the quality of the preparation was stable. |
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| Keywords: | Moxifloxacin Hydrochloride Liniment Preparation Qulity control HPLC |
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