Lidocaine treatment during synapse reformation periods permanently inhibits NGF-induced excitation in an identified reconstructed synapse of Lymnaea stagnalis |
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| Authors: | Shin Onizuka Seiji Shiraishi Ryuuji Tamura Tetsu Yonaha Nobuko Oda Yuko Kawasaki Naweed I Syed Tetsuro Shirasaka Isao Tsuneyoshi |
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| Institution: | (1) Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Miyazaki, Kiyotake-Cho, Miyazaki 889-1692, Japan;(2) Innovative Pathophysiology Research Group, Division of Cancer Pathophysiology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan;(3) Faculty of Medicine, Calgary Brain Institute, University of Calgary, Calgary, AB, Canada |
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| Abstract: | Purpose Nerve growth factor (NGF) has been reported to affect synaptic transmission and cause neuropathic pain. In contrast, lidocaine
has been used to reduce neuropathic pain; however, the effect of NGF and lidocaine on spontaneous transmitter release and
synapse excitation has not been fully defined. Therefore, the effect of NGF and lidocaine on nerve regeneration, synapse reformation,
and subsequent spontaneous transmitter release was investigated. We used Lymnaea stagnalis soma–soma-identified synaptic reconstruction to demonstrate that a transient increase in both frequency and amplitude of
spontaneous events of miniature endplate potentials (MEPPs) occurs following NGF treatment and a short burst of action potentials
in the presynaptic cell; in addition, the effect of lidocaine on NGF-induced synapse reformation was investigated. |
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