The tumour sink effect on the biodistribution of 68Ga-DOTA-octreotate: implications for peptide receptor radionuclide therapy期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

The tumour sink effect on the biodistribution of 68Ga-DOTA-octreotate: implications for peptide receptor radionuclide therapy

Authors:	Jean-Mathieu Beauregard Michael S. Hofman Grace Kong Rodney J. Hicks

Affiliation:	(1) Centre for Cancer Imaging, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Australia;(2) Molecular Imaging Research Group, Medical Imaging Department, Centre hospitalier universitaire de Qu?bec and Laval University, 6 rue McMahon, Quebec City, QC, G1R 3S2, Canada

Abstract:	Purpose Tumour sequestration of radiotracer may lead to decreased bioavailability in healthy tissue resulting in lower absorbed radiation dose to critical organs. This study aims to assess the impact of disease burden, body habitus and urinary excretion on the biodistribution of ⁶⁸Ga-DOTA-octreotate.

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