Therapeutic Hypothermia for Acute Neurological Injuries |
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Authors: | Lucia Rivera-Lara Jiaying Zhang Susanne Muehlschlegel |
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Institution: | 1.Department of Neurology,University of Massachusetts Medical School,Worcester,USA;2.Departments of Neurology (Division of Neurocritical Care), Anesthesia/Critical Care and Surgery,University of Massachusetts Medical School,Worcester,USA |
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Abstract: | Therapeutic hypothermia (TH) is the intentional reduction of core body temperature to 32°C to 35°C, and is increasingly applied
by intensivists for a variety of acute neurological injuries to achieve neuroprotection and reduction of elevated intracranial
pressure. TH improves outcomes in comatose patients after a cardiac arrest with a shockable rhythm, but other off-label applications
exist and are likely to increase in the future. This comprehensive review summarizes the physiology and cellular mechanism
of action of TH, as well as different means of TH induction and maintenance with potential side effects. Indications of TH
are critically reviewed by disease entity, as reported in the most recent literature, and evidence-based recommendations are
provided. |
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Keywords: | |
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