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Positron emission tomography imaging of CD105 expression with 89Zr-Df-TRC105

Authors:	Hao Hong Gregory W. Severin Yunan Yang Jonathan W. Engle Yin Zhang Todd E. Barnhart Glenn Liu Bryan R. Leigh Robert J. Nickles Weibo Cai

Affiliation:	(1) Department of Radiology, University of Wisconsin - Madison, Madison, WI, USA;(2) Department of Medical Physics, University of Wisconsin - Madison, Madison, WI, USA;(3) Department of Medicine, University of Wisconsin - Madison, Madison, WI, USA;(4) University of Wisconsin Carbone Cancer Center, Room 7137, 1111 Highland Ave, Madison, WI 53705-2275, USA;(5) TRACON Pharmaceuticals, Inc, San Diego, CA, USA

Abstract:	Purpose High tumor microvessel density correlates with a poor prognosis in multiple solid tumor types. The clinical gold standard for assessing microvessel density is CD105 immunohistochemistry on paraffin-embedded tumor specimens. The goal of this study was to develop an ⁸⁹Zr-based PET tracer for noninvasive imaging of CD105 expression.

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