On the Origin of the Triplet Puzzle of Homologies in Receptor Heteromers: Immunoglobulin Triplets in Different Types of Receptors |
| |
| Authors: | Alexander O. Tarakanov Kjell G. Fuxe Dasiel O. Borroto-Escuela |
| |
| Affiliation: | (1) St. Petersburg Institute for Informatics and Automation, Russian Academy of Sciences, Saint Petersburg, Russia;(2) Department of Neuroscience, Karolinska Institute, Stockholm, Sweden |
| |
| Abstract: | Based on our theory, we have discovered main triplets of amino acid residues in the GABAB1 receptor and several other neural receptors which seem to come from immunoglobulin chains and appear also as homologies in receptor heteromers. The obtained results strengthen our hypothesis that these triplets may “guide-and-clasp” receptor–receptor interactions playing a role, e.g., in neuroinflammation disorders. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
