Selective interaction of amyloid precursor protein with different isoforms of neural cell adhesion molecule |
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Authors: | Chen Ke-Ping Dou Fei |
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Institution: | (1) Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Institute of Life Science, Southeast University, Nanjing, 210009, China;(2) Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing, 100875, China; |
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Abstract: | Compare to the thoroughly studied beta-amyloid, the physiological function of amyloid precursor protein (APP) is not well
understood. We now had identified neural cell adhesion molecule (NCAM)-140 as a potential interaction partner of APP. Our
data indicated that NCAM-140, but not NCAM-180, binds to the conserved central extracellular domain of APP. We also found
that the phosphorylation levels of ERK1 and ERK2 were increased when cells were co-transfected with NCAM-140 and APP indicate
that the interaction between NCAM-140 and APP may involve the MAPK pathway. These findings demonstrated that NCAM-140 interacts
with APP, potentially playing a role in neurite outgrowth and neural development. |
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Keywords: | |
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