OPCML Gene as a Schizophrenia Susceptibility Locus in Thai Population |
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Authors: | Benjaporn Panichareon Kazuhiro Nakayama Wanpen Thurakitwannakarn Sadahiko Iwamoto Wasana Sukhumsirichart |
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Affiliation: | (1) Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Sukhumvit 23, Bangkok, 10110, Thailand;(2) Division of Human Genetics, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan;(3) Department of Psychiatry, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand; |
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Abstract: | Opioid-binding protein/cell adhesion molecule (OPCML) gene has been recently identified as a susceptibility gene for schizophrenia in Europeans. This study aims to investigate the association between single nucleotide polymorphisms (SNPs) in the OPCML gene and risk of schizophrenia in a Thai population. DNA samples of 115 schizophrenia patients and 173 normal controls were genotyped using high-resolution melting analysis and analyzed by chi-square test of SPSS software. We observed a strong association between an intronic SNP of the OPCML gene (rs1784519) and the risk of schizophrenia in the Thai population [P = 0.00036; odds ratio for the minor A allele, 2.11(1.57–2.84)]. The previously discovered SNP associated with schizophrenia in Europeans, rs3016384, also showed significant association with schizophrenia in the Thai population [P = 0.01; odds ratio of the minor T allele, 0.59 (0.44–0.79)]. Therefore, the OPCML gene is considered to be a schizophrenia-susceptible gene in the Thai population. |
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