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Synthesis and hypoglycemic activity evaluation of 7-alkoxyl-rhein |
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| Authors: | Xiaokang?Zhu,Xiaoli?Ye,Lujiang?Yuan,Yangping?Ding,Baoshun?Zhang,Xuegang?Li author-information" > author-information__contact u-icon-before" > mailto:xuegangli@yahoo.com.cn" title=" xuegangli@yahoo.com.cn" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
| Affiliation: | (1) College of Pharmaceutical Science, Southwest University, Chongqing, 400716, People’s Republic of China;(2) College of Life Science, Southwest University, Chongqing, 400715, People’s Republic of China; |
| Abstract: | A four-step microwave-assisted procedure was used to synthesize 7-alkoxyl-rhein derivatives 5a–e starting from emodin and 1-bromoalkanes. These compounds exhibited hypoglycemic activity by inhibiting α-glucosaccharase, which were influenced by the aliphatic chain length. Results showed that 5c displayed remarkable activity in vitro and in vivo. |
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