血小板胞内游离钙对尿毒症透析患者血压影响

目的探讨尿毒症患者中血小板胞内游离钙（Pt［Ca(2 )］i）与血压的相互关系。方法应用Frua-2荧光法测定了24例尿毒症患者（其中高血压组14例，非高血压组10例）透析前后Pt［Ca(2 )］i。结果发现高血压组透析前Pt［Ca（2 )］i与收缩压（SBP）和平均动脉压（MAP）有密切相关（γ＝0.91、P＜0．01和γ＝0.63，P＜0．05），而高血压组透析后及非高血压组透析前后Pt［Ca(2 )］i和SBP、MAP之间无相关性。透析前高血压组Pt［Ca(2 )］i显著高于非高血压组（P＜0.01）。结论尿毒症病人血压升高与Pt［Ca(2 )］i有线性相关关系，Pt［Ca(2 )］i静息水平的提高可能与尿毒症患者高血压的发生和发展有关。

Correlation of Platelet Cytosolic Free Calcium Concentration with Blood Pressure in Uremic Patient on Maintenance Hemodialysis

Objective We studied the platelet L Ca2 j i concentration in the urendc PatientS (n = 24 ) before and allerhemwhalysis. Method The patients it.erfl divided into tWo grouPS, hgnrtensive (BP321 .3/12. 7 kpa, n = 14 ) and non -- hypel'tensive (n = 10 ). Rafts in llypertensive PatienLs there was a close linear relahonship betWeen Platelet Ca2 j i with systolic blabpressme and mean ar'terial pressure (y = 0. gi, P < 0.01 and y = 0.63, P < 0.05 ) Mire dialysis, while there was no such relationship aller djalysis. In non -- hyperiensive patients there was no significant relationship betWeen them before and aller dialysis. ~OnThere was siMcant difference in platelet Ca2 ] i (222.25 1 18.64 nM versus 141. 16 t 8.58 nM, P < 0.01 ) between hypel'tensive and non -- hpertensive Patienls at the begining of' hemwhalysis.