磷霉素钠注射液与2种维生素类药物配伍的稳定性考察

目的考察室温下维生素C,维生素B6分别与磷霉素钠注射液配伍稳定性.方法采用紫外分光光度法测定8h内各配伍液中各自的含量变化情况,并进行了外观观察,pH值测量.结果室温条件下,磷霉素钠与VC配伍后其外观、pH值及含量都有变化,磷霉素钠与VB6配伍后其外观pH值及含量均无明显变化.结论上述条件下磷霉素钠不宜与VC混合输注,磷霉素钠与VB6配伍稳定.

Study on compatible stability of fosfomycin sodium with Vitamin B6 and Vitamin C

OBJECTIVE To Study the compatible stability of fosfomycin sodium with Vitamin B 6 and Vitamin C under normal atmosphere temperature. METHOD Determination of fosfomycin sodium, Vitamin B 6 and Vitamin C in compatible solution, and observation of pH and appearance of compatible solution within 8h by ultraviolet spectrophotometry and pH meter.RESULTS Under the normal atmosphere temperature, the content of fosfomycin and Vitamin C varies in compatible solution, with pH and the appearance. On the contrary, the content of fosfomycin and Vitamin B 6 is steady in compatible solution, with approximate stability of pH and appearance.CONCLUSION It is not suitable for fosfomycin to mix with Vitamin C, but adaptable to Vitamin B 6 .