糖尿病人白细胞吞噬功能的研究

本研究采用单层细胞法和电镜技术对糖尿病人及正常人的白细胞吞噬功能进行了对比研究。结果发现糖尿病组白细胞吞噬率、吞噬指数和溶菌率等指标均较正常对照组降低（Ｐ＜０．０１），多数糖尿病人白细胞的超微结构亦有异常改变。从而提示白细胞吞噬功能降低可能是糖尿病人易感染的重要因素之一。本文还就糖尿病人白细胞吞噬功能降低的原因，超微病理基础和方法等进行了讨论。

Study on Phagocytosis of Human Neutrophils in Diabetics

Infection is one of most commoncomplications in diabtes mellitus(DM).The neu-trophil plays an important role in the anti-infectionmechanism. A comparative study on phagocytosis ofP. Aeruginosa by human neutrophils in diabetic pa-tients and healthy volunteers was carried Out by meansof the monolayer of neutrophils and ultrastructural ob-servation in electronic microscopy. The results showedthat the rates of phagocytosis ,index of phagocytosisand rates of microbe lysis in DM group were muchlower than those in normal controls(P<0.01).Theultrastructure of neutrophils in diabetic patients be-came apparently abnormal during the process of neu-trophil phagocytosis. The results demonstrated thatthe impairment in phagocytosis of neutrophils may beone of the causes of severe and repeated infection in di-abetics.