The periaqueductal gray-raphe magnus projection contains somatostatin, neurotensin and serotonin but not cholecystokinin |
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| Authors: | Alvin J. Beitz R. David Shepard William E. Wells |
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| Affiliation: | 1. Departments of Neuroscience, Children''s Hospital Medical Center, and Neuropathology, Harvard Medical School, Boston, MA 02115, USA;2. Department of Psychology, Tufts University, Medford, MA 02155, U.S.A. |
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| Abstract: | The retrograde transport-HRP-immunocytochemical technique was employed to ascertain if the periaqueductal gray-raphe magnus projection arises from neurons containing somatostatin, neurotensin, serotonin or cholecystokinin. Following HRP injections into the raphe magnus (NRM) double-labeled cells containing HRP reaction product and somatostatin-, neurotensin- or serotonin-like immunoreactivity were identified in the midbrain periaqueductal gray (PAG). No cholecystokinin-like immunoreactive double-labeled neurons were found in the PAG. These results indicate that the PAG-NRM pathway contains somatostatin, neurotensin and serotonin but not cholecystokinin. |
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| Keywords: | nucleus raphe magnus somatostatin neurotensin serotonin cholecystokinin |
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