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The periaqueductal gray-raphe magnus projection contains somatostatin, neurotensin and serotonin but not cholecystokinin
Authors:Alvin J. Beitz   R. David Shepard  William E. Wells
Affiliation:1. Departments of Neuroscience, Children''s Hospital Medical Center, and Neuropathology, Harvard Medical School, Boston, MA 02115, USA;2. Department of Psychology, Tufts University, Medford, MA 02155, U.S.A.
Abstract:The retrograde transport-HRP-immunocytochemical technique was employed to ascertain if the periaqueductal gray-raphe magnus projection arises from neurons containing somatostatin, neurotensin, serotonin or cholecystokinin. Following HRP injections into the raphe magnus (NRM) double-labeled cells containing HRP reaction product and somatostatin-, neurotensin- or serotonin-like immunoreactivity were identified in the midbrain periaqueductal gray (PAG). No cholecystokinin-like immunoreactive double-labeled neurons were found in the PAG. These results indicate that the PAG-NRM pathway contains somatostatin, neurotensin and serotonin but not cholecystokinin.
Keywords:nucleus raphe magnus   somatostatin   neurotensin   serotonin   cholecystokinin
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