纤维支气管镜下气囊导管给药治疗空洞型肺结核的临床研究

目的观察经纤维支气管镜(简称纤支镜)气囊导管注药介入治疗空洞型肺结核的临床疗效。方法将痰找抗酸杆菌阳性临床明确诊断初治空洞型肺结核60例,分为化疗加纤支镜下气囊导管注药治疗组和化疗加支气管腔内导管注药对照组,观察两组临床疗效。结果强化期2月后痰菌阴转率、空洞病灶有效率、空洞闭合率、治疗组分别为96.9%、93.8%、68.8%,未出现继发感染和结核播散。对照组分别为65.4%、61.6%、30.8%,对照组有4例出现继发感染和2例结核播散。两组比较差异有统计学意义(P<0.01)。结论经纤维支气管镜气囊导管注药治疗空洞型肺结核是一种有效安全的介入方法,且无明显的并发症及毒副反应,值得临床推广应用。

Clinical observation of trans-fibrobrenchoscope balloon catheter interventional therapy in the treatment of cavitary pulmonry tuberculosis

Objective To determine the clinical effect of trans-fibrobrenchoscop(eBFS) balloon catheter interventional therapy in the treatment of pulmonary tuberculosis.Methods 60 patients of diagnosed by bacterio-male Sputum to part for two bundle:One group are treated by trans-fibrobrenchoscope balloon catheter interventional therapy combined with anti -tuberculosis drug therapy,the other are treated by bronchoscope catheter interventional therapy combined with anti -tuberculosis drug therapy.Results At the end of the treatment the sputum bacterial conversion to negative rate is 96.9%,radiographic improvement rate is 93.8% and cavity closing rate is 68.8 % in the treatment group all of which are higher than in the controls (65.4%,61.6% and 30.8 respectively) (P <0.01).C o n c l u s i o n trans -fibrobmuchoscope balloon catheter interventional therapy treatment bacterio-male of cavitary pulmonary tuberculosis is a reliable therapy method,and no obvious complication and adverse reaction are observed. It is to be worth to extend.