洛度沙胺联合0.05 g/L丝裂霉素C预防67例翼状胬肉复发的疗效观察

目的观察0.1%洛度沙胺滴眼液联合0.05 g/L丝裂霉素C对翼状胬肉切除加带蒂结膜瓣移位术后预防胬肉复发的作用.方法对67例(71眼)原发性和复发性翼状胬肉随机分成两组,治疗组36例(38眼),对照组31例(33眼).两组均施行胬肉切除加带蒂结膜瓣移位术.治疗组术后滴用0.1%洛度沙胺滴眼液,每天4次,共3个月,同时滴用0.05 g/L丝裂霉素C,每天2次,共6天,随访11～20个月,平均13个月.结果3例(3眼)失访.治疗组翼状胬肉复发率2.78%,对照组复发率31.25%,P＜0.01,治疗组角膜创面愈合延迟.结论翼状胬肉切除加带蒂结膜瓣移位术后滴用0.1%洛度沙胺滴眼液联合0.05 g/L丝裂霉素C能有效地预防翼状胬肉复发.

Combined Lodoxamide and mitomycin C 0.05 g/L in Preventing recurrence of 67 cases of pterygium

Objective To observe the preventive effect of topical Lodoxamide 0. 1% eye drops and mitomycin C 0. 05 g/L eye drops on pterygium recurrence following pterygium excision and pedicled conjunctival transplantation. Methods 67 patients (71 eyes)of primary and recurrent pterygium were randomly divided into two groups : 31 patients (33 eyes)as control group, 36 patients (38 eyes) as treatment group received Lodoxamide 0. 1 % eye drops four times a day for 3 months and mitomycin C 0. 05 g/L eye drops twice daily for 6 days after surgery. Postoperative follow-up ranged from 11 to 20 months (mean,13 months). Results 3 patients(3 eyes)lost follow-up. The recurrent rate was 31. 25% in the control group and 2. 78% in the treatment group, (P<0. 01) . The side effects in treatment group were as follows: delayed heal in cornea wound in 36 eyes. Conclusion Instillation of Lodoxamide 0. 1% eye drops and mitomycin C 0. 05 g/L eye drops after the pterygium excision and pedicled conjunctival transplantation can decrease pterygium recurrent rate.