The Development of a Predictive Method for the Estimation of Flux Through Polydimethylsiloxane Membranes. IV. Application to a Series of Substituted Quinolines |
| |
Authors: | Matheson Lloyd E. Hu Meng-wei |
| |
Affiliation: | (1) Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, 52242;(2) Lederle Laboratories, Pearl River, New York, 10965 |
| |
Abstract: | The steady-state flux of 33 substituted quinoline derivatives was determined in polydimethylsiloxane membranes using isopropyl alcohol as the receiver solvent. These diffusants constituted a diverse group of compounds possessing a wide range of hydrophobic, steric, and electronic characteristics. Various parameters representing these physicochemical properties such as cyclohexane–water fragmental constants, molar refractivity, Hammett's constants, intramolecular hydrogen bonding ability, melting point, and mole fraction solubility were employed to develop empirical models capable of relating the rate of diffusion to these characteristics of either the substituent on the quinoline ring or the compound itself. |
| |
Keywords: | membrane diffusion linear free energy relationships partition coefficient molecular volume diffusion prediction quinolines |
本文献已被 SpringerLink 等数据库收录! |
|