| 丙泊酚与东莨菪碱合用对大鼠学习记忆的影响 |
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| 引用本文： | 郭龙龙,程桥,林贞贤. 丙泊酚与东莨菪碱合用对大鼠学习记忆的影响[J]. 中国医疗前沿, 2011, 0(10): 17-18 |
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| 作者姓名： | 郭龙龙 程桥 林贞贤 |
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| 作者单位： | 山西医科大学第一临床医学院麻醉科;泰山学院生物科学与技术系; |
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| 摘 要： | 目的观察丙泊酚与东莨菪碱合用对大鼠学习记忆的影响。方法健康成年雄性SD大鼠64只,体重200-250g,随机分为4组：对照组（Con组,n=16）、丙泊酚（Pro组,n=16）、东莨菪碱组（Sco组,n=16）、丙泊酚＋东莨菪碱组（Pro＋Sco组,n=16）。Pro组、Pro＋Sco组大鼠腹腔注射丙泊酚50mg/kg作为诱导剂量,待翻正反射消失后在腹腔追加50mg/kg加深麻醉。每组的一半大鼠在注射丙泊酚后12h开始进行Morris水迷宫测试,另外的一半大鼠在注射丙泊酚后3d开始进行Morris水迷宫测试,连续3d,Pro＋Sco组、Sco组大鼠在每天水迷宫测试前20 min腹腔注射东莨菪碱0.8 mg/kg。结果与Con组比较,Sco组大鼠出现了学习记忆障碍;与Sco组比较,Pro＋Sco组腹腔注射丙泊酚后1、2d学习记忆障碍加重,而注射丙泊酚后3～6d学习记忆功能测试结果差异无统计学意义。结论丙泊酚与东莨菪碱合用可以短暂加重大鼠学习记忆功能障碍。
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| 关 键 词： | 丙泊酚 学习记忆 东莨菪碱 |
The Effect of Propofol and Scopolamine on Learning and Memory in Rat |
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| GUO Long-long,CHEN Qiao,LIN Zhen-xian. The Effect of Propofol and Scopolamine on Learning and Memory in Rat[J]. China Healthcare Innovation, 2011, 0(10): 17-18 |
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| Authors: | GUO Long-long CHEN Qiao LIN Zhen-xian |
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| Affiliation: | GUO Long-long,CHEN Qiao,LIN Zhen-xian.Department of Anesthesia,First Clinical Medical College,Shanxi Medical University,Taiyuan 030001,China Corresponding author: CHEN Qiao |
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| Abstract: | Objective To observe the effect of propofol combined with scopolamine on learning and memory in rat.Methods sixty-four SD rats weighting 200-250g were randomly divided into 4 groups: group A control(n=16);group B propofol(n=16);group C scopolamine(n=16);and group D propofol+scopolamine(n=16).In group B and D propofol 50mg/kg for the induction dose intraperitoneal injected and after the righting reflex disappeared,additional 50mg/kg deepen anesthesia.In group C and D scopolamine 0.8mg/kg was injected intrape... |
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| Keywords: | Propofol learning and memory Scopolamine |
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