| 甲氨蝶呤联合环磷酰胺治疗类风湿关节炎的疗效观察 |
| |
| 引用本文： | 王妤,李军霞,郝慧玲,李小峰,王彩虹.甲氨蝶呤联合环磷酰胺治疗类风湿关节炎的疗效观察[J].中国医疗前沿,2011(10):29-30. |
| |
| 作者姓名： | 王妤 李军霞 郝慧玲 李小峰 王彩虹 |
| |
| 作者单位： | 山西医科大学第二医院风湿免疫科; |
| |
| 摘 要： | 目的探讨甲氨蝶呤（MTX）联合环磷酰胺（CTX）治疗类风湿性关节炎（RA）的临床疗效和安全性。方法将50例活动期RA患者随机分为治疗组和对照组各25例。治疗组给予甲氨喋呤（MTX）＋环磷酰胺（CTX）;对照组给予甲氨喋呤（MTX）＋来氟米特（LEF）。两组均治疗12周。观察两组治疗后的临床疗效和不良反应。结果治疗12周后,治疗组在关节肿胀、关节压痛、晨僵时间、ESR及CRP等临床和实验室指标的改善均优于对照组,差异均有统计学意义（P〈0.05）;治疗组不良反应少于对照组,差异有统计学意义（P〈0.05）。结论 MTX联合CTX治疗RA临床疗效好,不良反应小,安全性高。
|
| 关 键 词： | 甲氨蝶呤 环磷酰胺 类风湿关节炎 |
Comparative Study on Clinical Efficacy of Methotrexate Combined with Cyclophosphamide in the treatment of Rheumatoid Arthritis |
| |
| WANG Yu,LI Jun-xia,HAO Hui-ling,et al..Comparative Study on Clinical Efficacy of Methotrexate Combined with Cyclophosphamide in the treatment of Rheumatoid Arthritis[J].China Healthcare Innovation,2011(10):29-30. |
| |
| Authors: | WANG Yu LI Jun-xia HAO Hui-ling |
| |
| Institution: | WANG Yu,LI Jun-xia,HAO Hui-ling,et al.The Second Hospital of Shanxi Medical University,Taiyuan 030001,China |
| |
| Abstract: | Objective To compare the efficary and adverse reaction of methotrexate(MTX) plus cyclophosphamide(CTX)(Group MTX+CTX) and methotrexate(MTX) plus leflunomide(LEF)(Group MTX+LEF) in the treatment of active rheumatoid arthritis(RA).Methods 50 cases were divided into secend groups.25 partients of the combination group administrated LEF and MTX;25 partients of the combination group recerived LEF and CTX.The indexes of the efficiency assessment included rest pain,moring stiffness,gripping strength,count of joint ... |
| |
| Keywords: | Methotrexate Cyclophosphamide Rheumatoid arthritis |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
