口服普萘洛尔在健康中国人药物动力学的性别差异(英文)

目的:确定口服普萘洛尔(Pro)的体内分布与代谢是否在健康中国人中存在性别二态性.方法:12名健康志愿者(6男,6女)口服单剂量Pro 80 mg,其血浆Pro浓度用HPLC荧光法检测,药物动力学参数用MCPKP软件计算.结果:女性的AUC和C_(max)分别比男性高74％和99％,相反,Cl_o和V_d却分别比男性低109％和120％.女性T_(1/2)较长,但和男性比无显著差异,其他药物动力学参数未发现明显性别差异.结论:中国女性比男性有一个较高的Pro口服生物利用度,部分归因于她们在服药后对Pro的整体清除率较低和表观分布容积较小.

Sex differences in pharmacokinetics of oral propranolol in healthy Chinese volunteers

AIM:To determine if the gender-based dimorphism of the distribution and metabolism of oral propranolol (Pro) exists in the healthy Chinese volunteers. METHODS: Twelve subjects (6 M and 6 F) were given an 80 mg single oral dose of Pro. Plasma Pro levels were determined by HPLC with fluorescence detector and the pharmacokinetic parameters were calculated by using the MCPKP program. RESULTS: AUC and Cmax in females were about 74 % and 99 % higher than those in males (P<0. 05), whereas oral clearance and apparent distribution volume were 109 % and 120 % lower in females than in males (P <0.05),respectively. The T1/2 tended to be longer in females (P>0. 05). No differences in any other kinetic parameters were found between the sexes. CONCLUSION : The higher oral bioavailability (AUC and Cmax) of Pro in Chinese women is in part caused by their lower oral clearance and volume of distribution.