Rose bengal-modified gold nanorods for PTT/PDT antibacterial synergistic therapy |
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| Affiliation: | 1. Guangxi Key Laboratory of Natural Polymer Chemistry and Physics, Nanning Normal University, Nanning, China;2. College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China;1. Department of Companion Animals, Silla University, Busan 46958, South Korea;2. Bi Biophotonics Co., Ltd., Gimpo-si, Kyunggi-do 10090, South Korea;3. Department of Food Biotechnology, Silla University, Busan 46958, South Korea;4. Department of Chemistry, Seoul Women''s University, Seoul 01797, South Korea;1. Department of Physics and Astronomy, Western Kentucky University, Bowling Green, KY 42101, United States;2. Department of Biology, Western Kentucky University, Bowling Green, KY 42101, United States;1. Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;2. Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;1. School of Pharmacy, Fudan University, No.826, Rd. Zhangheng, Shanghai 200000, China;2. Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Science, No.150, Rd. Fucheng, Hangzhou 310000, China;3. Department of Stomatology, Huashan Hospital North, Fudan University, No.108, Rd. Luxiang, Shanghai 200000, China |
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| Abstract: | In this study, Rose Bengal (RB) was loaded onto mesoporous silica coated gold nanorods (AuNR@SiO2-NH2) to form a novel multifunctional platform for antimicrobial therapy (AuNR@SiO2-NH2-RB). The platform combines the photothermal functions of AuNR and the photodynamic functions of RB to effectively inactivate bacteria under irradiation. Moreover, AuNR@SiO2-NH2-RB showed negligible cytotoxicity and good blood compatibility. Therefore, this work has potential significance for the development of new antibacterial agents. |
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