Systemic inflammation after spinal cord injury: A review of biological evidence,related health risks,and potential therapies |
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| Affiliation: | 1. Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA;2. Pulmonary, Allergy, Sleep, and Critical Care Medicine Section, VA Boston Healthcare System, Boston, MA, USA;3. Harvard Medical School, Boston, MA, USA;1. Department of Gastrointestinal Oncology, Institut Jules Bordet, Brussels, Belgium;2. Clinica Oncologica e Centro Regionale di Genetica Oncologica, Università Politecnica delle Marche, AOU delle Marche, Ancona, Italy;3. Department of Life, Health and Environmental Sciences, University of L''Aquila, L''Aquila, Italy;4. Department of Experimental Medicine, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy;5. Erasme University Hospital, Brussels, Belgium;6. Université Libre de Bruxelles, Brussels, Belgium |
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| Abstract: | Individuals with chronic traumatic spinal cord injury (SCI) develop progressive multi-system health problems that result in clinical illness and disability. Systemic inflammation is associated with many of the common medical complications and acquired diseases that accompany chronic SCI, suggesting that it contributes to a number of comorbid pathological conditions. However, many of the mechanisms that promote persistent systemic inflammation and its consequences remain ill-defined. This review describes the significant biological factors that contribute to systemic inflammation, major organ systems affected, health risks, and the potential treatment strategies. We aim to highlight the need for a better understanding of inflammatory processes, and to establish appropriate strategies to address inflammation in SCI. |
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