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Flavonoids and stilbenoids as a promising arsenal for the management of chronic arsenic toxicity
Affiliation:1. Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) – Guwahati, Changsari, Kamrup, Assam 781101, India;2. Danylo Halytsky Lviv National Medical University, Lviv, Ukraine;3. National University of Pharmacy, Kharkiv, Ukraine;4. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, India;5. Ivan Franko National University of Lviv, Lviv, Ukraine;6. Andrei Krupynskyi Lviv Medical Academy, Lviv, Ukraine;1. Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, Uttar Pradesh, India;2. Embryotoxicology Laboratory, Environmental Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), VishvigyanBhavan, 31, Mahatma Gandhi Marg, Lucknow 226 001, Uttar Pradesh, India;3. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201 002, Uttar Pradesh, India;4. Analytical Chemistry Laboratory, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research, Lucknow 226001, Uttar Pradesh, India;1. School of Life Science, College of Environment and Resource, Shanxi University, Taiyuan 030006, China;2. Department of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Shanxi Medical University, Taiyuan 030001, China;1. Toxicology laboratory, Raymond Poincaré hospital, AP-HP, Garches, France;2. MasSpecLab Platform, UMR1173, Inserm, Montigny-le-Bretonneux, France;3. Department of Forensic Medicine and Pathology, Raymond Poincaré Hospital, AP-HP, Garches, France;4. Paris Ouest Research Clinic Unit, Ambroise Paré hospital, AP-HP, Boulogne-Billancourt, France;1. Department of Pharmacology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey;2. Department of Medical Biology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey;3. Department of Anatomy, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey;4. Department of Pathology, Faculty of Medicine, Gaziosmanpasa University, Tokat, Turkey
Abstract:Rapid industrial and technological development has impacted ecosystem homeostasis strongly. Arsenic is one of the most detrimental environmental toxins and its management with chelating agents remains a matter of concern due to associated adverse effects. Thus, safer and more effective alternative therapy is required to manage arsenic toxicity. Based on existing evidence, native and indigenous plant-based active biomolecules appear as a promising strategy to mitigate arsenic-induced toxicity with an acceptable safety profile. In this regard, various phytochemicals (flavonoids and stilbenoids) are considered important classes of polyphenolic compounds with antioxidant and chelation effects, which may facilitate the removal of arsenic from the body more effectively and safely with regard to conventional approaches. This review presents an overview of conventional chelating agents and the potential role of flavonoids and stilbenoids in ameliorating arsenic toxicity. This report may provide a roadmap for identifying novel prophylactic/therapeutic strategies for managing arsenic toxicity.
Keywords:Arsenic toxicity  Arsenicosis  Detoxification  Resveratrol  Naringenin  Chrysin  Rutin
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