Exposure to Polystyrene nanoparticles induces liver damage in rat via induction of oxidative stress and hepatocyte apoptosis |
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| Affiliation: | 1. Cytology and Histology Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt;2. Textile Research Division, National Research Centre, Dokki, Cairo, Egypt;3. Faculty of Veterinary Medicine, King Salman International University, Ras Sudr, South Sinai, Egypt;4. Biochemistry and Chemistry of Nutrition Department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt;5. Packaging and packing materials Department, National Research Center, Dokki, Cairo, Egypt;1. Department of Agriculture, Biodiversity and Forest, Postgraduate Program in Conventional and Integrative Veterinary Medicine, Curitibanos, SC 89520-000, Brazil;2. Postgraduate Program in Pharmacy, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil;3. Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, SC 88040-900, Brazil;4. VERTÁ, Laboratory of Veterinary Diagnostic, Institute of Veterinary Research and Diagnostic, Curitibanos, SC 89520-000, Brazil;1. College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, PR China;2. College of Chemistry, Jilin University, Changchun 130012, PR China;1. School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China;2. State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150006, China;3. Department of Medicine, Renal Electrolyte and Hypertension Division, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19019, USA;4. Faculty of Education, Wakayama University, Wakayama, 640-8441, Japan;1. Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji''nan, 250062, Shandong, People''s Republic of China;2. Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 4108, Brisbane, Queensland, Australia;3. Department of Respiratory Medicine, Qilu Children''s Hospital of Shandong University, 250022, Ji''nan, Shandong Province, People''s Republic of China;1. Department of Occupational and Environmental Health, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, People''s Republic of China;2. Center of Experimental Teaching for Public Health, Experimental Teaching and Management Center, Chongqing Medical University, Chongqing, 400016, People''s Republic of China;3. Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People''s Republic of China;4. Department of Health Laboratory Technology, School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, People''s Republic of China;5. Molecular Biology Laboratory of Respiratory Disease, Institute of Life Sciences, Chongqing Medical University, Chongqing, 400016, People''s Republic of China;6. Dongsheng Lung-Brain Disease Joint Lab, Chongqing Medical University, Chongqing, 400016, People''s Republic of China |
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| Abstract: | Plastic products are widely used in different applications. Thus, exposure of human and other organisms to these products may affect their biological system. The current study was conducted to investigate the potential deleterious effect of Polysterene nanoparticles (PS-NPs) on the liver and to state the cellular and molecular mechanisms associated with exposure to PS-NPs.30 male rats were divided randomly and equally into 3 groups; control (distilled water), low dose (3 mg/kg/day) and high dose (10 mg/kg/day) exposed group via oral gavage for 5 successive weeks. PS-NPs caused elevation in ALT, AST and MDA, upregulation of apoptosis-related genes and significant decrease in GSH and mRNA expression for antioxidant-related genes (Nrf-2 and GPx). Moreover, alterations in hepatic tissue architecture and positive caspase-3 expression was noticed in a dose- dependent manner. Collectively, PS-NPs can induce hepatoxicity in rats in a dose dependent manner, so the health risk of PS-NPs should not be ignored. |
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| Keywords: | Polystyrene nanoparticles Oxidative stress Apoptosis Liver Rats |
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