Ozone-induced retinal vascular reactivity as assessed by optical coherence tomography angiography |
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| Institution: | 1. Department of Ophthalmology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey;2. Department of Physical Therapy and Rehabilitation, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey;3. Department of Ophthalmology, Sultan Abdulhamid Han Training and Research Hospital, University of Health Sciences, Istanbul, Turkey;1. Nanosensors Laboratory, Research & Development Institute, Vale do Paraíba University, 12244-000 São José dos Campos, São Paulo, Brazil;2. Dynamics of Cellular Compartments Laboratory, Research & Development Institute, Vale do Paraíba University, 12244-000 São José dos Campos, São Paulo, Brazil;3. Bionanotechnology Laboratory, Research & Development Institute, Vale do Paraíba University, 12244-000 São José dos Campos, São Paulo, Brazil;1. Department of Geriatric, Dazhou Central Hospital, Dazhou, Sichuan, China;2. Department of Neurology, Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China;1. Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;2. Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran |
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| Abstract: | BackgroundThis study aimed to investigate the retinal vascular reactivity (RVR) of the macular and peripapillary capillary network in response to ozonated autohemotherapy (AHT) using optical coherence tomography angiography (OCTA).MethodsThis was a single-centre prospective study. All participants that were planned to have a combination of major and minor ozone AHT underwent a complete ocular examination and OCTA imaging before and after the ozone AHT. Foveal avascular zone (FAZ) metrics and vessel density (VD) of superficial (SCP), deep capillary plexus (DCP), and radial peripapillary capillary (RPC) plexus were assessed using the built-in software.ResultsA total of 40 right eyes of 40 individuals were included. No significant differences were observed for the mean values of the FAZ metrics and choriocapillaris flow area following ozone AHT compared with baseline values (p > 0.05). The mean whole VD of SCP and DCP was 47.80 ± 2.18% and 53.09 ± 3.00% before treatment, which decreased to 47.68 ± 2.7% and 52.38 ± 3.07% after treatment (p = 0.660 and p = 0.097, respectively). No significant differences were observed in the vascular densities of both SCP and DCP in any quadrant (p > 0.05). The RPC density did not show significant alterations compared with baseline values, except the inferior-hemi region. The VD in the inferior-hemi peripapillary quadrant was significantly increased after ozone AHT (p = 0.034).ConclusionThe ozone AHT did not cause evident RVR in the macular area, whereas the peripapillary area showed a partial response. |
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