基于CiteSpace对中医药治疗蒽环类所致心脏毒性的可视化分析

目的 通过文献计量学方法，评估中医药治疗蒽环类所致心脏毒性的研究趋势，并探讨机构合作、研究热点和前沿趋势。方法 计算机检索Web of Science、中国知网（CNKI）、万方、中国生物医学（CBM）和维普（VIP）数据库，检索2000年1月1日—2022年10月31日发表的关于中医药治疗蒽环类所致心脏毒性的中英文文献。运用文献计量学软件CiteSpace对国家、机构、期刊、作者、被引文献和关键词进行可视化分析。结果 检索到1134篇关于中医药治疗蒽环类所致心脏毒性的论文，其中英文文献237篇，中文文献897篇。该领域发文量逐年增加，发文量最多的国家是中国（117篇）；英文文献中发文量最多的机构是阿卜杜勒·阿齐兹国王大学（9篇），中文文献发文量最多的机构是湖南中医药大学（45篇）。中医药治疗蒽环类心脏毒性主要以中成药研究为主，主要的治疗方向是蒽环类所致的心力衰竭和心肌病，心脏毒性早期更关注心肌损害，之后更关注心力衰竭。蒽环类心脏毒性研究分为临床研究和实验研究。该领域的早期研究主要集中在临床研究，近10年主要以分子机制研究为主；实验研究的早期主要以动物实验为主，近4年更关注细胞实验。氧化应激一直是该领域研究的主要趋势，氧化应激、凋亡和自噬分子机制及三者之间的关系研究将是该领域研究的主流趋势。结论 分子机制研究及氧化应激、凋亡和自噬机制之间的关系是中医药治疗蒽环类所致心脏毒性的研究热点和趋势，文献计量学分析结果为中医药研究人员提供了有价值信息，有助于研究者发现潜在的合作者和机构，发现该领域的热点问题和探索新的研究方向。

Traditional Chinese medicine in treatment of anthracycline-induced cardiotoxicity: A bibliometirc analysis via CiteSpace

Objective To evaluate the global research trend of traditional Chinese medicine (TCM) in the treatment of anthracycline-induced cardiotoxicity through bibliometric methods, and explore international cooperation, research hotspots and frontier trends. Methods The Chinese and English articles on TCM in the treatment of anthracycline-induced cardiotoxicity published from January 1, 2000 to October 31, 2022 were searched by Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang, Chinese Biomedical Database (CBM) and Weipu Database (VIP). The bibliometrics software CiteSpace was used for visual analysis of countries, institutions, journals, authors, cited references and keywords. Results A total of 1134 papers on TCM in the treatment of anthracycline-induced cardiotoxicity were searched, including 237 papers in English and 897 papers in Chinese. In this field, the number of publications increased gradually throughout the year, China had the largest number of publications (117); King Abdulaziz University (9) had the largest number of publications in English and Hunan University of Chinese Medicine (45) had the largest number of publications in Chinese. TCM in treatment of anthracycline-induced cardiotoxicity was mainly based on the research of Chinese patent medicines, and the main treatment direction was heart failure and cardiomyopathy caused by anthracyclines. The research on cardiotoxicity focuses more on myocardial damage in the early stage, and more on heart failure afterwards. Anthracycline cardiotoxicity research was divided into clinical research and experimental research. Clinical research was mainly concentrated in the early stage of the study, and in the last 10 years, it was mostly focused on the study of molecular mechanisms. Experimental studies were mainly concerned with animal studies, and in the last four years, more attention had been paid to cellular experiments. Oxidative stress has always been the main trend of research, and the molecular mechanism of oxidative stress, apoptosis and autophagy as well as the relationship among them would be the mainstream trend in this field. Conclusion The study of molecular mechanisms and the relationship among oxidative stress, apoptosis, and autophagy mechanisms were the hot spots and trends in the study of TCM in the treatment of anthracycline-induced cardiotoxicity. The results of bibliometric analysis provided valuable information for TCM researchers, helped researchers to find potential collaborators and institutions, discover hot issues in this field, and explore new research directions.