Immune-mediated food reactions in irritable bowel syndrome |
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| Affiliation: | 1. KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Leuven, Belgium;2. Translational Research Centre for Gastrointestinal Disorders, Center for Intestinal Neuroimmune Interaction, Leuven, Belgium;1. Marsico Lung Institute / Cystic Fibrosis Center, University of North Carolina at Chapel Hill, 6009 Thurston Bowles Bldg, Chapel Hill, NC, 27599-7248, USA;2. Department of Medicine, University of North Carolina at Chapel Hill, NC, 27599-7248, USA;3. Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, NC, 27599-7248, USA;2. Department for Neurobiology, Institute for Biological Research “Siniša Stanković” - National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000, Belgrade, Serbia;1. CSIR-Institute of Genomics and Integrative Biology, New Delhi, India;2. Academy of Scientific and Innovative Research, Ghaziabad, India;3. Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK;1. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy;2. Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, Pisa, Italy;1. Neurodegeneration New Medicines Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, 92037, USA;2. Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA, 92093, USA;3. Department of Neurology, Yale School of Medicine, New Haven, CT, 06510, USA |
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| Abstract: | Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by recurrent abdominal pain and an altered defecation pattern. Depending on the criteria used, it affects between 5 and 10% of the general population and has a serious impact on quality of life. Most patients with IBS show an induction or exacerbation of their symptoms, particularly abdominal pain, after eating certain foods. This raises the question of the role played by food in IBS pathophysiology. In this review, we describe the multiple risk factors of IBS, and we give an overview of the role of food as a trigger of IBS, distinguishing between immune and non-immune reactions to food. We finally highlight recent findings identifying an immune-mediated mechanism underlying food-induced abdominal pain in IBS. |
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